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WPU RESEARCH HUB · SMART SCHOLARLY DISCOVERY

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Crossref · failed DataCite · 20 found DOAJ · 20 found Europe PMC · deferred capacity
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Journal ArticleOpen access

High density lipoprotein cholesterol / C reactive protein ratio in heart failure with preserved ejection fraction

ESC Heart Failure

Online resource

Abstract Aims The impacts of high density lipoprotein cholesterol (HDL‐C) as an anti‐inflammatory and C reactive protein (CRP) as inflammatory properties on the pathogenesis of heart failure were reported.

Heart failure with preserved ejection fractionInflammationHigh density lipoprotein cholesterol/C reactive protein ratioLeft ventricular diastolic functionRight ventricular systolic function
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Journal ArticleOpen access

How nurses address psychosocial needs in patients with advanced heart or lung failure: a qualitative interview study

BMC Nursing

Online resource

Abstract Background Patients with advanced heart failure or lung failure often experience significant changes in psychosocial needs, which may affect their quality of life, emotional wellbeing, and daily functioning.

Psychosocial needsHeart failureLung failureNursesPalliative care
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Journal ArticleOpen access

Nurse-coordinated home-based cardiac rehabilitation for patients with heart failure: A scoping review

International Journal of Nursing Sciences

Online resource

Objectives: This study aimed to review and summarize the studies of nurse-coordinated home-based cardiac rehabilitation for patients with heart failure. Methods: The review was performed using Arksey and O’Malley’s scoping review framework.

Cardiac rehabilitationHeart failureHome care servicesNurseNursing care
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Journal ArticleOpen access

The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials

Nutrition Journal

Online resource

Abstract Background A cornerstone of conventional dietary advice is the recommendation to replace saturated fatty acids (SFA) with mostly n-6 polyunsaturated fatty acids (PUFA) to reduce the risk of coronary heart disease (CHD).

Saturated fatPolyunsaturated fatOmega 6Diet heart hypothesisCoronary heart disease
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Journal ArticleOpen access

Identification and reporting of heart failure with preserved ejection fraction in Sub-Saharan Africa: a scoping review of diagnostic approaches, echocardiographic assessment, and evidence gaps

The Egyptian Heart Journal

Online resource

Abstract Background Heart failure with preserved ejection fraction (HFpEF) is increasingly recognized as a major heart failure phenotype globally; however, its diagnosis is complex and is recommended to require integrated assessment of clinical features, echocardiographic abnormalities, and biomarkers.

Heart failure with preserved ejection fractionSub-Saharan AfricaEchocardiographyDiastolic dysfunctionNatriuretic peptides
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Journal ArticleOpen access

Growth Failure in Children with Congenital Heart Disease

Children

Online resource

Background/Objectives: Growth failure is a common complication in children with congenital heart disease (CHD), yet its underlying mechanisms and consequences remain incompletely understood.

congenital heart diseasegrowthfailure to thrivemalnutritiondevelopmental
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Other Scholarly ResourceOpen access

What is the evidence supporting the use of GLP-1 agonists for treating heart failure with preserved ejection fraction?

Zenodo

Online resource

The use of GLP-1 agonists in HFpEF is supported by evidence showing improvement in heart failure-related symptoms and reduction in hospitalizations, though impacts on mortality are less consistent.

GLP-1 agonistsheart failurepreserved ejection fractiontreatmentevidence
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DissertationCheck access

Investigating the role of PP2A-B55α in the heart

Monash University

Online access details

This thesis investigates the role of an enzyme known as B55α in the heart. First, B55α was studied in the whole heart using mouse models. It was discovered that B55α regulates growth of heart muscle cells in response to stress. This response differed between male and female mice, demonstrating sex-dependent roles for this enzyme in cardiac biology. Molecular profiling experiments identified several novel targets of the B55α e…

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This thesis investigates the role of an enzyme known as B55α in the heart. First, B55α was studied in the whole heart using mouse models. It was discovered that B55α regulates growth of heart muscle cells in response to stress. This response differed between male and female mice, demonstrating sex-dependent roles for this enzyme in cardiac biology. Molecular profiling experiments identified several novel targets of the B55α enzyme in heart muscle cells. Findings from this thesis point to an important role for B55α in heart function and provide a foundation for further study in settings of heart disease and failure.

Proteomics and intermolecular interactions (excl. medical proteomics)Animal cell and molecular biologyCardiology (incl. cardiovascular diseases)
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DissertationCheck access

Investigating the role of PP2A-B55α in the heart

Monash University

Online access details

This thesis investigates the role of an enzyme known as B55α in the heart. First, B55α was studied in the whole heart using mouse models. It was discovered that B55α regulates growth of heart muscle cells in response to stress. This response differed between male and female mice, demonstrating sex-dependent roles for this enzyme in cardiac biology. Molecular profiling experiments identified several novel targets of the B55α e…

Read full excerpt

This thesis investigates the role of an enzyme known as B55α in the heart. First, B55α was studied in the whole heart using mouse models. It was discovered that B55α regulates growth of heart muscle cells in response to stress. This response differed between male and female mice, demonstrating sex-dependent roles for this enzyme in cardiac biology. Molecular profiling experiments identified several novel targets of the B55α enzyme in heart muscle cells. Findings from this thesis point to an important role for B55α in heart function and provide a foundation for further study in settings of heart disease and failure.

Proteomics and intermolecular interactions (excl. medical proteomics)Animal cell and molecular biologyCardiology (incl. cardiovascular diseases)
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DissertationCheck access

Targeting Novel Genes Using CRISPR activation (CRISPRa) in Murine Postnatal Heart

Monash University

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Heart failure, affecting approximately 65 million individuals globally, is a leading cause of death worldwide. Currently, there are no treatment to reverse its progression. Dysregulation of gene expressions is a key determinant of cardiac pathology outcomes. Yanie’s PhD aimed to address this by investigating the use of a novel gene editing approach called CRISPR activation (CRISPRa) to restore the altered gene expression. Her…

Read full excerpt

Heart failure, affecting approximately 65 million individuals globally, is a leading cause of death worldwide. Currently, there are no treatment to reverse its progression. Dysregulation of gene expressions is a key determinant of cardiac pathology outcomes. Yanie’s PhD aimed to address this by investigating the use of a novel gene editing approach called CRISPR activation (CRISPRa) to restore the altered gene expression. Her work is among the first to demonstrate successful use of CRISPRa-mediated gene activation in an adult mouse heart, highlighting its potential as a therapeutic tool for restoration of gene expression to improve heart failure outcomes.

Gene and molecular therapy
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DissertationCheck access

Targeting Novel Genes Using CRISPR activation (CRISPRa) in Murine Postnatal Heart

Monash University

Online access details

Heart failure, affecting approximately 65 million individuals globally, is a leading cause of death worldwide. Currently, there are no treatment to reverse its progression. Dysregulation of gene expressions is a key determinant of cardiac pathology outcomes. Yanie’s PhD aimed to address this by investigating the use of a novel gene editing approach called CRISPR activation (CRISPRa) to restore the altered gene expression. Her…

Read full excerpt

Heart failure, affecting approximately 65 million individuals globally, is a leading cause of death worldwide. Currently, there are no treatment to reverse its progression. Dysregulation of gene expressions is a key determinant of cardiac pathology outcomes. Yanie’s PhD aimed to address this by investigating the use of a novel gene editing approach called CRISPR activation (CRISPRa) to restore the altered gene expression. Her work is among the first to demonstrate successful use of CRISPRa-mediated gene activation in an adult mouse heart, highlighting its potential as a therapeutic tool for restoration of gene expression to improve heart failure outcomes.

Gene and molecular therapy
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Journal ArticleOpen access

Comparative Analysis In The Treatment Of Myocardial Infarcted Patients In The Tertiary Care Hospital Of Peshawar Against American Heart Association (ASA) Treatment Guidelines

Journal of Rawalpindi Medical College

Online resource

Abstract Objective: To analyze pharmacotherapy provided in the hospital for MI indications and outcomes and to assess the protocols that are practiced for MI patients against the AHA and NICE guidelines.

Myocardial Infartionbeta blockeracute coronary syndromeGuidelinesMortality
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Other Scholarly ResourceOpen access

Updating the Standard for a Normal Unfixed Heart Weight Based off an Inclusive Sample Size

RVU Research Week, Office of Research and Scholarly Activity

Online resource

Classic organ weight references, such as those by Rutty et al. (1997) and Molina & DiMaio (2015), are widely utilized.

FOS: Clinical medicineOrgan SizeColoradoUtah
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Journal ArticleOpen access

ITRI Biofilm Prevented Thoracic Adhesion in Pigs That Received Myocardial Ischemic Induction Treated by Myocardial Implantation of EPCs and ECSW Treatment

Cell Transplantation

Online resource

This study tested the hypothesis that ITRI Biofilm prevents adhesion of the chest cavity. Combined extracorporeal shock wave (ECSW) + bone marrow-derived autologous endothelial progenitor cell (EPC) therapy was superior to monotherapy for improving heart function (left ventricular ejection fraction [LVEF]) in minipigs with ischemic cardiomyopathy (IC) induc…

Medicine
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Journal ArticleOpen access

Genetic associations of adult height with risk of cardioembolic and other subtypes of ischemic stroke: A mendelian randomization study in multiple ancestries.

PLoS Medicine

Online resource

BackgroundTaller adult height is associated with lower risks of ischemic heart disease in mendelian randomization (MR) studies, but little is known about the causal relevance of height for different subtypes of ischemic stroke.

Medicine
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Journal ArticleOpen access

Corrigendum to “Metabolic risk factors in first acute coronary syndrome (MERIFACS) study” [Indian Heart J 2022 Jul–Aug;74(4):275–281]

Indian Heart Journal

Online resource

SurgeryDiseases of the circulatory (Cardiovascular) system
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PreprintOpen access

Oxygenation as a Memory-Bearing Bridge: How Delay, Averaging and Measurement Shape Apparent Apnea–Desaturation–Bradycardia Cascades in Preterm Infants

Zenodo

Online resource

This paper examines how the apparent sequence of apnea, desaturation, and bradycardia in preterm infants is shaped by measurement and physiology rather than by mechanism alone. The author builds a linear-filter model of the breathing–oxygenation–heart-rate chain and proves eleven results.

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PreprintOpen access

Resonance Distance, Phase Locking and Spectral Protection in Neonatal Cardiorespiratory Coupling: What Rhythm Measures Can and Cannot Show

Zenodo

Online resource

This paper asks what neonatal cardiorespiratory rhythm measures actually measure under explicit signal models and finite windows, and proves eleven propositions and three lemmas. On measurement validity: a phase is defined only where the envelope exceeds the noise, with error bounded by the noise-to-envelope ratio; heartbeats sample the cardiac modulation s…

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PreprintOpen access

Resonance Distance, Phase Locking and Spectral Protection in Neonatal Cardiorespiratory Coupling: What Rhythm Measures Can and Cannot Show

Zenodo

Online resource

This paper asks what neonatal cardiorespiratory rhythm measures actually measure under explicit signal models and finite windows, and proves eleven propositions and three lemmas. On measurement validity: a phase is defined only where the envelope exceeds the noise, with error bounded by the noise-to-envelope ratio; heartbeats sample the cardiac modulation s…

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Journal ArticleOpen access

Supplemental Figure and Tables

figshare

Online resource

Supplemental materials for the paper by Jenkins et al. titled "Adverse childhood family environment is associated with altered cardiovascular regulation during exercise: the CARDIA Study" in the American Journal of Physiology: Heart and Circulatory Physiology

Exercise physiologyCardiovascular medicine and haematology not elsewhere classified
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